ButchB, I went to school in Athens. I' d take 32 all the way to cincy, then get on 275 around to 50. I wouldn' t take 50 to cincy from Athens. 32 is all four lane, and doesn' t have to go through the billions of small towns that 50 goes through, it doesn' t go through the big towns either, like Chillicothe. Good luck.