Thanks, guys.
"Most efficient"is determined by your setup (draw weight, draw length, etc...). "Optimal" for the individual bowhunter's desired useage......can be quite different. He may not set up his bow with the most "efficiency" (per the bow's specs).....and there's nothing wrong with that.
My bow "might" shoot a 350 gr arrow 300fps. I might choose to shoot a 450gr arrow 260fps to achieve my "optimal" setup. Tuning for this would (or might be)be much different than tuning for maximum bow efficiency.
When "I" think of "tuning", though....I think center shot, first. I then think of vane clearance. If I can get to that point.....it's pretty much "personal preference", from there. Does that make sense?