I usually leave mine loaded (but unprimed) if I'm going to be hunting again the next day or in a few days IF the following conditions exist:
1. It is not very humid weather (powder does absorb moisture)
2. I can leave the weapon outside the house (unheated garage, shed or even trunk of car) where it won't go through major temp. changes
3. State laws allow transportation of charged weapon.

I have also used a balloon during wet/rain/snowy conditions and it worked fine. After the shot it was just GONE.

Good Luck