It's not the size, but what you do with it.

I have used Muzzy 3 blade 100gr and know that if I am off or the deer flinches and I hit bone the Muzzy will go throught it. I am know I get good flight and good penetration. I what a good exit wound to get the trail to follow. I hunt in think area's and we don't always get to see the deer go down and with a stream near by and running water, I don't always hear it either.