RE: If he is quartering away??
It really depends as he walks, you know, one foot in front of the other.
If the furthest shoulder is back when you hit with your arrow, you risk a shoulder shot which could lead to the arrow stopping in the shoulder and not having an exit wound.
So a few variables come to mind and have been mentioned...
Degree of angle, height of your tree stand (assuming your in a tree) and where the shoulders are when you release.