As much as I love my 7mm-08 Rem I will have to agree with bigbulls on this one. The 7mm-08 and the 25-06 are both great cartridges in their own right, but they are also very close to what you already have. Now if I had to pick one of the two it would be the 7mm-08 Rem, especially if you are considering letting your wife shoot it. Have you looked into the 260 Rem?