Most all of the new inlines can shoot 150 grains loads. Some require that it be in pellet form. Will they shoot it accurate? If you play with enough loads, I am sure you will find one projectile that will shoot accurate.

The question is ... why do you shoot 150 grains of powder. Do you do so because you can or because you like the recoil? Most of the Knights, and T/C rifles will shoot magnum charges with good accuracy. Now they make scopes to complement the 150 grains rifles. Heck of a sales pitch in my book.

I shoot 70 grains of 3f powder and a 460 (or bigger) conical.