Most Encores and TC Omega can, Knight Disc, Savage 10ML2can no problem. In factyou will see most rifles sold now days advertise they they can shoot up to 150g of 777. I use to shoot 150g 3 pyrodex pellets in my Knight and my TC Omega, so I know first hand, until I got educated by this board (Cayugad and Sabotloader primarily is who I owe my education to on hot loads and Powerbelts--but several others also, I could NOT figure our why I was loosing deer with 150g loads in a TC Omega at 30 40 and 50 yards with PB). The question is what does that get you shooting a magnum charge, take a look at my "How to Use a Ballistic Program Thread", here:

http://www.huntingnet.com/forum/tm.aspx?m=2878035

and see what it means to go up in bullet speed by 100fps and how that impacts arc out to 150 yards,
couple that with the bullet discussion here and see how various bullets pancake out or worse yet fragment:

http://www.huntingnet.com/forum/tm.aspx?m=2884930

With high charges with some bullets pancake them out or fragment on close shots, not good, for back east woods hunting. High charge shot accurately with a premiuum bullet is killing out to 175 yards with 3" high at 100 yard zero. So if you shoot high charge accuratelyWITH premiuum bullet your OK, with fragmenting bullet your not OK. You loose accuracy if your recoil sensitive with 150g charge.
Chap