I don't have one single weapon I will always go to. I consider the conditions I will be hunting, length of shots offered,the weather .... even if i am going to be in a particular blind or walking during a still hunting day.
More often than not I'm carrying a 6.5 X 55 Swede sporter, or a Mauser 98 in .243, or a Savage 110 in 30/06.
When the weather is real nasty i have a swede 6.5 X 55 in a composite stock and a treated paint on finish.