Nope, brass same strength. But the older cylinders were not made to handle the pressures of H110 loads or 44mag pressures. But all the newer Rugers can. So 45LC can handle about the same pressures as 44mag. Just depends on what you want. I have always opted for the 44 mag since I have a choice or hot factory loads but can load them down with Unique powder. But you have trouble buying higher pressure 45colt factory loads and would have to handload them hot.

James, I would be very careful in loading that 45LC to 1300fps with a 300gr bullet. I have seen some pressure signs with lilgun at 1200fps. Brass didn' t last that long either before splitting. I know the hornady manual said it can be done, but as always with reloading, I would consult Hodgdon, Sierra, Speer, and maybe Nosler manuals also. They don' t recommend that hot of a load for the 45LC.