Picking up a .243 mainly for antelope....and possibly the new mule deer rifle, but mainly antelope. On an antelope with some friends and their friends/fathers, quite a few guys were using 95gr noslers from their .243 and were blowing right through them. Same case with my .270 130gr soft points, so I plan to use more of a soft style 90-100gr soft.

No experience with the .25-06, believe the 115 or 117gr loads tend to be the most popular, cousin used his .25-06 on muley's in wyoming and the deer dropped so fast when he came back on target it was as if it disappeared, I remember him saying that 120gr was the max load.....though not sure he was using 120, or 115, 117, I think with any of those you'll be pretty safe.