Bolting to the frame of the house is not the same as bolting to a slab of concrete. It would take about 15 seconds with a chainsaw to cut the wall and free the safe. It would be a lot more work if you had to cut through concrete.

Also I do not think it makes any difference if the safe is in the garage or inside the house. Once the bad guy is inside the garage or the house and can operate without being seen from the outside the only thing that will deter them is the time it take to do what they want to do.