I would use my old bear load: the Keith .358429 semiwadcutter (173-grain bullet) cast of hard lead, or heat-treated, and 14 grains of Alliant 2400 powder. I have fired this load through grizzly bear heads and it penetrated about 6" into the ground after going through the bear' s heads!! Shoot them on the end of the nose as they approach you. The bullet will travel through the nasal passages, and enter the brain. Instant bear kill!!