ORIGINAL: Ridge Runner

ok, unless you take out the CNS, central nervous system, if you want DRT deer, your best bet, is use a bullet of high velocity, of light construction (middle of the road weight for caliber) and hit them at the point of most resistance, The shoulder blade.
Upon impact, just before the bullet starts to penetrate, a massive shockwave starting at the point of impact, goes in all directions (away from POI) it sends blood backwards through the major blood vessels, while the shockwave travels up the spine to the brainstem, this overwhelms the CNS causing all systems to shut down immediately.
now if the bullet does make it to the vitals it is more or less a moot point, the legs have allready jerked up and the deer is on its way down.
I've taken many many deer like this with calibers starting with the 223 all the way up to the 7mm STW, in larger slower calibers the deer still dies, with less meat damage but they are running as they go down, the best cartridges for this here on our small deer are the 243/6mm and 25/06.
all animals are about 70% water, the liquid displacement is what causes all this, like shooting a gallon jug of water.
I use this shot alot, due to liberal bag limits I'm not that worried about losing both shoulders, its only good for burger anyhow.
RR