Even tho each rifle has its own characteristics and preferences in ammo the method I find most cost effective and quick. Make the call to the Sierra tech guys....ask them what powder consistently performs best in their tests. They test more guns, bullets and powder than anyone I have worked with and they will tell you that there is a combination of components that nearly always shoots well in a given chambering. I start there....in 37 years of handloading it has never failed me for a starting point.