Audette/ladder method- becasue I don't want to burn through $50 worth of components to find a good load.

Primers- I universally use Federal 210s or WLR primers and IMR 4064, 4895, 4350, and Varget pretty much cover the spectrum for the rifle cartridges I reload, with the exception of RL-22 which is well known as a nearly ideal powder for 6.5x55 and it hasn't let me down either.

If you start with well established 'accuracy loads' for staple cartridges like .223, .308, and 30-06, its hard to go wrong.