The 30-06 is a better White-tail round because you can use the heavier 180 grain bullets in close range situations to reduce meat damage and get better penetration necessary for odd agles sometimes encountered in thick brush hunting situations. Since we are talking white-tails this is commonly where you will find them. With reloads or Hornady light mags the 30-06 shoots every bit as fast and flat as the 270 or 280 using more mass and bullet diameter. A better question is what will the 270 or 280 do that the 30-06 can' t