Yes they sure can. Powerbelt bullets recommends 348g minimum for elk.
A 405g powerbelt would be maximum for Colorado. We have that stupid "bullet can not excess twice the bore diameter" Rule. 50cal = 1" long. .50Cal is almost minimum for hunting elk during muzzle loader season.
Try this to learn how to use them correctly.
http://www.gbofreeforums.info/ThePow...orum/index.php