Either would do fine, though may I suggest you look at other rifles aside from Ruger.....sure consider them, but look at/consider others.....

As to the calibers.....I think the .270 would be more versatile than the .25-06, but a .30-06 would be even more so, though I'm not sure you have any ambitions of hunting anything bigger than deer.....? on elk....I'd much prefer a .30-06 to a .270 or .25-06, though if you do become a elk nut.....you may be purchasing another rifle.

.25-06 is a nice round, esp for deer, as is the .270, max loading for a .25 is about 120gr, where as a .270 is 150 or 160grs, which on a bigger animal is a considerable addition IMO.

Though in my .270 I use 130gr, to m this is your ideal .270 load, and in a .25-06 the ideal load is usually 115gr or 117, or if for something lighter 100gr, though I feel the 115/117gr loads are perfect for the .25-06

If you don't own a rifle, aside from that .22, I think the .270 would probably be my choice, get a .270 though I wouldn't limit myself to just Ruger, look around, see what you like best.