In regards to POI you'll just have to shoot them as every rifle and load act differently. I have a barnes load and Nosler load where the poi change isn't that great but still enough that I wouldn't hunt without verification and fine tuning. IME the barnes TSX is an accurate bullet and I haven't found a rifle yet that wouldn't shoot it (I reload but i here factory ammo guys saying the same thing).

As far as will the barnes or other non-lead buller take down deer and hog the answer is yes. The wound channel is smaller then a cup and core bullet but does the job. If your into breaking them down with a shoulder shot barnes are excellent, penetration/weight retention is very high but I've found they waste very little meat when such a shot is taken.

FYI, the E-tip is made by Nosler. Maybe able to get more info from the website or Nosler forum. I have zero experience with the E-tips.