I carry both, and I hunt in grizz country every year. I have yet to run into one while hunting. If ever a grizz were to charge me I would go the pepper spray first. I agree with Dan, that few hunters could hit a bear during a charge. If you draw your gun first I would honestly try to fire a missing shot in front of it in attempt to kick up dirt in the bears face. Or well out in front of it so the bear can see it and hopefully become frightened. Like I said before I plan to spray first, I know it will slow the bear down, and more than likley send him in the other direction. If he shakes it off and is still in the mood to pursue, then I will shoot to kill with my sidearm.(be it my .41Mag, .44Mag, or my .454 Casull)After I sprayed the bear, hopefully I will have calmed down a bit collect my thoughts and will be able to make a accurate shot.