For long range shooting, 300 to 500 yards. (It is my question so I am limiting it to my personal limit of 500 yards).
Do you prefer using one of the ultra kicking magnums and maybe not being able to shoot that hard kicking rifle as well or shooting a standard caliber like the 25-06 to 30.06 that is more comfortable to shoot well but may not have as much power at long range. What is your opinion on the trade off? Remember I am talking real world in the field accuracy not bench accuracy.

For me I prefer the standard calibers with generally better field accuracy for long range shooting of deer and antelope. I am willing to give up a little generally worse field accuracy with the magnums at long range for more power on elk and bear.