I've seen probably a handful of deer shot with a 25-06, and I have yet to see it anchor a deer in its tracks.
This year is the first time I've ever personally used a quarter bore. My 25wssm didn't drop a deer dead in its tracks either.
My 243 always drops 'em dead in there tracks, and my 7mm Rem Mag (rifle of choice), really knocks 'em dead. [align=right]
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Well in all fairness not many cartridges do but I have had a pretty good sucess rate of DRT's using 308,30-06,270 and 7 mags..everything else they run.