I've seen probably a handful of deer shot with a 25-06, and I have yet to see it anchor a deer in its tracks.

This year is the first time I've ever personally used a quarter bore. My 25wssm didn't drop a deer dead in its tracks either.

My 243 always drops 'em dead in there tracks, and my 7mm Rem Mag (rifle of choice), really knocks 'em dead.