I don't see a problem with the 150's but why not go to the 165's for the longer range shots? They will buck the wind a little better and still shoot relativly flat. I load 165's for hunting and 168's for paper punching. My pet load is either a Speer 165gr BTSP or a Sierra 168gr Macth King over 74grs of IMR-4350, Win. brass and Fed.-215 primer;(NOTE THIS IS MAX OR NEAR MAX CHARGE IN MOST RELOADING BOOKS) both shoot close enough to the same zero out to 600yds to take down a deer. But like you I limit myself to 400-450yds on game. Out of my Sendero I get an average 3200fps muzzle velocity from both bullets.