I like the 25-06 with nosler 110 grain accu-bond. Flat shooting and hard hitting. Shoot the rifle that you can place your shots with. I know a guy who hunts with a .243 and kills everything he points at. Why? Because he knows his rifle and can shoot it accurately. He understands bullet performance and downrange trajectory. In other words, he can hit what he aims at. Most of the guys I hunt with take heart/lung shots. Good percentage shot; wastes little meat; animals bleed out from the shot. Quick and clean.