I think the only problems you would get into is: 1.with the safety not being on thecorrect side, buta lot of crossbowshave the safety on both sides and one could always reach over the stock (carefully) to operate the safety and 2. the fancier thumbhole stocks would be angled for right or left handed. I shoot mine (Horton) left-handed every so often 'cause sometimes a shot in the field calls for it. Last year I probably shoulda shot left handed at a buck I was tracking when he caught me off guard. He came back at me to my right and had me kinda pinned down. I already had the crossbow up and on my right shoulder so I had to twist way around to my right without moving my feet. I pulled it off and hit thespot I was trying to hit (he was @ 23 yds), but it was a little uncomfortable and shakey there for a few seconds. Grndhntr