TJEN - Anaphylactic shock has nothing to do with bullets. It's a severe allergic reaction some people have to certain things, like bee stings or food allergies.

And I'm thinking you haven't shot many 22/250s. I own one and have shot it (and my brother's 220 Swift) with all weights of bullets and I've NEVER had one come apart due to air resistance. That's an old wive's tale.

Granted you'll never get a swagged .22 LR slug up to that velocity in a .22/250...wrong diameter for starters. When I suggested people compare the 40 gr 22 LR with a 40 gr from .22/250 it was never my intent to suggest a literal swap of the bullets. There are a couple here who suggest velocity makes no difference and one at least who thinks bullet performance makes no difference. Both notions are pure horse feathers.

I once heard another absurdity in a gunstore one day when a fellow was telling me his bullets "went too fast to open up or expand."

As for the length of the wound channel......that depends on what the bullet does. And I have seen largefragments of bullets that actually blew up come out the other side of deer...something you will rarely ever see a .22 LR do. I've shot large jackrabbits with a 243 and seen my bullet go through the animal like an AP. (And I don't think they were going too fast to open up.) And for those who don't think bullet performance makes any difference, those rabbits staggered off a ways before they fell over and died. When the same bullets did decide to perform and open up, they almost blew the rabbit in half. Obviously those rabbits were dead before they hit the ground.

We need to be careful about making sweeping statements about what bullets can and can't do. Sometimes this can be very far from fact. JMHO