I think you can argue all day about what one cartride has to offer over another. I believe the bottom line is you need to decide what you'll be happy with and make your purchase from that decision. Read the ballistics from many different calibers you are considering and go to a chart like that is on
www.biggameinfo.comFrom that you can determine down range impact energy down range velocity, bullet drop and the whole nine yards. If you plan on spending that kinda money on a custom rig be sure your happy with what you decide.