RE: Overgunned for Whitetail
Out of all the rifles you mention many of them would serve you out to the 120 yards you mention is the normal long shot. However you metioned that you have had at least one 300 yard shot. So if you are going to settle on ONE rifle to do all your bidding you're stuck with one that you shoot well, has a decent flat trajectory, or at least one you know well enough to compensate for on long shots.
But since you own so many different rifles in different rounds I guess you're covered for different opportunties (as long you can predict which opportunities you're going to have!)
Me, ... if it was a matter of choosing just one I guess I'd go with the 280.