My favorite is my 7mm Rem Mag.
I get a laugh out of these threads especially the "every deer I've shot with X caliber has dropped dead in it's tracks" folks.
I shot my mule deer exactly where I was aiming from 175 yards and it ran 50 yards before falling dead. Was it poor shot placement? No. Was it poor bullet performance? No. Was I under or over gunned? No.
The shot took out both lungs and didn't even hit a rib. I'm not even sure the deer knew that it was hit, it simply spun around and started running off before it collapsed. I didn't ruin any meat whatsoever. I think the results would have been the same whether I was shooting a .243 or a .338 Win Mag. I like my 7mm Rem Mag and am comfortable shooting it, that's why it is my favorite!