I suggest you give this siimple test a try. You might be surprised at the results.
I shot a buck one morning @ 8:15....after I'd been in my stand since 4:00, that morning. I was shooting my Allegiance at 71#'s and it was 14 deg. outside.
I think I'd pass that test.
One shot? No problem. 60? I don't like it.
Letting down Bry? Good point. Something to think about, for sure.