I tested a whole bunch of high BC bullets in my Savage, see here:

http://www.the-gleasons.com/this_is_my_savage_10_ml_page.htm

Which bullet you pick depends on which one your gun shoots best at. I would shoot what the gun manufacturer recommends, say the Knight Red Hot or the Hornady XTP at whatever power they say is best and get the gun grouping with the manufacturer recommended load. You then know you have an accurate barrel/gun. Once you get that shooting well then branch out to say a

1) Parker Ballistic Extreme 275g (you MAY have to change the sabot out, since that bullet is exactly .450 and it is loose in my Savage) or better yet

2) Barnes TMZ 290g

3) 300g Bonded SW.

Any of those bullets have good to excellent terminal performance and will reach out there, sighted in 3" high at 100 yards,you will be within3" at 200 yards. If you look at the Ballistic Charts of a Nosler Partition, and sight it in at 3" high at 100 (say with 120g of loose 777), your good to about 180 yards with a 300g Hollow Point bullet. After 200 yards most MLers start dropping off the table. 250 is a really really long shot for a MLer. Most shots for a ML are less than 100 yards. Big bullets going slow have a lot of killing power, ballistics of most MLer arevery similar tothe 45-70 in the CF rifle world, and you can read about what they did to buffalo in the 1800's. Chap Gleason