I'll take the most accurate as long as it's reasonable with performance. This year I used the 300 gr XTP because it was easily the winner on accuracy over my old favorite the 300 gr Barnes Expander MZ.
One shot. One bullet right where I wanted to put it, and one deer dead in it's tracks! I've heard some stories of the XTP fragmenting, and I'm not disputing them, but if you put it through skin, muscle, and small bones, then into the heart/lung area it will do the job! The ability to put it where you want it is more important to me!
A heart/lung shot with about any .50 bullet will put meat in the freezer, but a miss or worse (a non-vital area hit) too often ends in frustration.