I just ran the 300g barnes original ss vs. the 250g sst on computer

300g barnes @ 2000 fps 3" high at 100 yds
200 yds -4" 1525 ft/lbs
300 yds -26" 1150 ft/lbs

250g sst @ 2100 fps 3" high at 100 yds
200 yds -4" 1679 ft/lbs
300 yds -28.5"784 ft/lbs

So, you dont have to give up anything with a heavier bullet!
Rule #1 of shooting keep your finger off the damn trigger
#2 dont trust computer run shooting data
In my experience it has been pretty darn close!