Cocked and locked is considered the safest...short of not having a round in the chamber. Cocked and locked looks mighty dangerous but most people forget that with cocked and locked there are actually TWO safeties involved before the gun will fire, i.e. the regular safety AND the grip safety. You gotta disable both to shoot it. This is how all the cops who carry 1911's are taught to carry.

I've not personally heard of anyone having accidental discharge in this configuration.