I'm a big fan of the Barnes, but I don't doubt any of the claims about Nosler and Speer GDHP.
I've shot one deer with a Barnes Expander and the results were awesome, by the truest sence of the word.
I currently shoot the Barnes Spitfire 245g and get clover leaf groups at 100yds. I took my two best bucks with this bullet.
The main thing is to find a proven bullet (nosler, gold dot or barnes) that gives you the accuracy you are looking for...all barrels are different.
here is another thread about the Spitfire 245g
http://www.huntingnet.com/forum/tm.aspx?m=2458656