I think if I were you, I'd double check my arrows, going for something middle of the road as far as weight goes, and I'd bet a 125 grain BH add a little "whip" to your arrows if you are properly spined right now at 45#. As far as what to set your pins at, that's a matter of personal preference. I like a little tighter set-up, because it gives me a smaller margin of error if I misjudge distance. My setting for a 270-ish FPS bow are 24, 32, 40, 48, 56, with a 5 pin set up. That allows me the best options for hunting, leaving a few inches drop from one pin to the next, I can pull high 24 on a 30yd shot, and still take home some venison.