I would stick with a 240 gr cast bullet.......no hollow point. I have my doubts that anything would be gained by trying to make a 44 throw a 300 gr bullet. A 240 grain is already a big bullet for the cartridge. I'd rather have some extra velocity and push behind the thing. But then I've never been eaten by a grizzly, so I don't know for sure. I doubt any of us have ever had the pleasure of putting our theories to the test on this.