Born and raised in Alaska. My dad and my Father in law both used nothing but the 30-06 for taking moose, caribou, and bear.
I have my father in laws gun now. The same Winchester model 70 30-06 he bought brand new in 1968, and I have taken game in Al, Fl, Tn, and Alaska with it.
The good old 30-06 is a very versatile caliber, ...you can plink with it or go after North American big game depending on the load.
I have only had one caliber of deer rifle (excluding muzzleloaders) and see no reason to switch.