For my .50s I like anywhere fron 250 to 350 grain bullets whether sabot or conical. The rifle makes the final decision for me on which one by it's accuracy. Some rifles like the lighter end, some the heavier, but most .50s I've owned will shoot something in that range accurately. Most of my deer have been killed with 300 grain Barnes or XTPs. All but one have been the "bang-flop" result and the one that travelled went about 30 yards. Put a good bullet in the heart/lung area ant the blood trail will be short.