I used a 300gr XTP and 100gr Pyrodex R/S to drop a deer in it's tracks this year. My rifle shoots to approximatelythe same POI @ 100 yards with 100gr Pyrodex or 80gr T-7. Just happened to be using Pyrodex that day since it was pouring rain and I didn't know how moisture might affect the T-7. [&:]
I guessed the shot to be about 80 yards, but it was actually closer to 100. Quartering-towards me and I put the bullet in front of the shoulder. No exit & a dead deer dropped on the spot!
Unfortunately it was pouring rain, I had my 7 year old with me, it was getting dark, and the creeks were rising fast (and we had to cross one), so I field dressed it as quickly as possible and got it out of there! No time for an autopsy, but I could tellthe lungs were destroyed!