Yes i am shooting a deer creek northwest rifle in .45cal After selling all of my inlines, this is the only rifle i have right now with a twist that can shoot powerbelts. Im using 80 grains pyrodex p with a Copper series 225 grain aerotip powerbelt. Makes nice big holes, bloody blood trails. Next up is the 223 grain powerbelt platinum to try out.
My dad and brother use the 295s in their 50's with 90 grains RS. No trouble with them at all.
This is my .45 and the deer i got in September.

Had to follow this long 5 yard blood trail and a long 20-30 foot skid mark that was smeared with blood,

entrance,

Exit,
With the lower powder charges that i use, they bust through bone and keep goin.