ORIGINAL: idunno
If that is the case I have seen several times where a 410 has been recommended.
A load of #6 shot at close range will do anyone in and doesn't have the penetration power to go through walls behind the assailant. If the revolver is still the gun of choice, then maybe Taurus' new judge would be worth taking a look at. It fires .45 Long colt or 410 shotshells. Check this out...
http://www.taurususa.com/whatsnew/revolvers.cfm
That's debatable...I certainly would NOT want to trust defending my life to birdshot in a .410, though...I think it is negligent for Taurus to market their 410 shotshell revolver (using shotshells, not the 45 Colt) as a self defense weapon...not enough penetration in the bad guy...