Bow - Through the middle of the lungs. I shot a 10-pt straight thru the heart once and he ran 200+ yds without a drop of blood, I only found with with some luck intuition.

Gun - Heart shot if 50yds or under. Otherwise, middle of the lungs behind the front leg. I avoid the shoulder unless dropping them in their tracks vs 50 yds away is important; too much meat to ruin in the shoulder.