If I am 99% sure my shot will be 25 yards or less I have no problems shooting a relative heavy arrow. To me that would be 450 to 500 grains. I would never shoot anything heavier for the hunting I do. IBowhunt areas a lot of the time where I know there is a really good chance my shot will be 35 to 45 yards that's when I prefer a lighter arrow, 340/350 grains.
I have hunted with arrows as light as 320 grains out of a 60# bow and got complete pass throughs
Dan