I do most of my hunting with a bow and find myself still trying for the perfect "boiler room" shot even with a muzzleloader. The muzzleloader adds the option of a "quartering toward" shot (which I took this season and had the old bang-flop result) but I still go for the heart - lungs. In the past 8 or 10 years (averaging 1 a year)using a .50 with Barnes or XTP bullets I've had one deer go less than 30 yards. The rest dropped on the spot!
About allof the deer with the bow go less than 60 yards with a good double lung shot, many much less. I believe my shortest recovery with the bow was 18 yards on a double lung shot.