It really doesn't matter as long as a guy can place his bullet where it needs to be...

We killed 44 deer this year, I had to track just as many hit with a .270 as a .243...

btw...Don't tell my 16 year old niece a 22-250 won't kill deer, she has dropped 7-8 in the past 4 years with the 60gr Nosler Partition...Never lost a one, always exits...Frankly, I would bet she is a better shot than many who slam the smaller cartridges...

If it's legal and you feel froggy, shoot a 50 cal. BMG as far as I'm concerned...