The LOS distance is irrelevant. (Your 150' radius isn't relevant. Forget it!) It's the distance that the force of gravity has to work on the arrow (perpendicular to the center of the Earth) that is important. In your instance you would shoot it as if it were 50 yards and you'd hit the mark at 70.7 yards LOS at either 45 degrees uphill or downhill. It's one of those instances, like navigating in the fog, when you have to let go of how it feels and trust your instruments. I love 3D courses with big uphill/downhill shots like this to emphasize the point and make people comfortable with these shots. If you're ever going to hunt mountain goats you need to be comfortable with these shots.