I would gp with the 300 Wby. Mag. it' s Weatherby' s most popular caliber, and you will be able to find ammo for it almost anywhere. There are 22 different types of factory loads to choose from. A-Square, Federal, Hornady, Remington, Speer, and Weatherby all make ammo for the 300 Wby. Mag. The bullet choice range from 150 gr. to 220 gr. from A-Square, Sierra, Trophy Bonded Bear Claw, Nosler Partition, Nosler Ballistic Tip, Hornady Interlock, Hornady Round Nose Expanding Remington PSP Core-Lokt, Remington PSP Boat-tail, Speer Grand Slam, and Barnes X.

You will have enough power to take any animal in North America as long as you choose the right bullet, and do your part. Good luck.